Does methotrexate affect the immune system? Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Almost all autoimmune diseases require the immune system be suppressed to some degree, because 'overactivity' of the immune system is what drives the illness. How long do you take methotrexate for rheumatoid arthritis? 4. How long will methotrexate take to start working? It's not immediate. Many RA patients will start to experience an improvement in symptoms after six to eight weeks on methotrexate, but it can take up to six months before you would reach the full benefits of taking the drug. Is Methotrexate a prescription drug? Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites.
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